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[9] [10] If nausea becomes severe or persistent, patients should contact their healthcare provider, as dose adjustment may be necessary

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Even after one use, the tip of a needle can develop microscopic barbs or hooks. These tiny deformities cause the needle to tear through the skin rather than gliding through it, which significantly increases the chance of capillary damage

SUSTAIN 6 was the only trial in the population pharmacokinetic model to include subjects with severe renal impairment ( n = 33), and the covariate effect for severe renal impairment might therefore be confounded by a trial effect